Fluconazole for yeast infections

A vaginal yeast infection is uncomfortable yet usually simple to treat. Fluconazole is one pill by mouth that clears most of them. A licensed clinician reviews your answers, and if it fits, your prescription ships to your door.

It is the same single-dose treatment a clinician would prescribe in person, and it works about as well as the creams without a week of nightly applications.

In the UK, Canada and Australia you can get this pill from a pharmacist without an appointment. In the US it still needs a prescription. We make getting that prescription quick.

What it treats

An uncomplicated vaginal yeast infection, the kind caused by an overgrowth of Candida. The usual signs are:

Itching or irritation around the vagina and vulva.
Burning, including during urination.
Thick, white, clumpy discharge.
Redness, swelling or soreness, sometimes with pain during sex.

What we prescribe

One intake, reviewed by a clinician. If a yeast infection is the clear answer, you get the single-dose pill. If your history points to infections that keep returning, the clinician can set up a longer plan.

Fluconazole 150 mgsingle dose: One pill, taken once with or without food. Itching often eases within a day, and the rest settles over two to three days. For severe symptoms a clinician may add a second dose 72 hours later.
Recurrent coursethree doses: For infections that keep coming back, one 150 mg dose on days 1, 4 and 7 brings the current one under control before any longer plan.
Maintenance planweekly, up to 6 months: If you get four or more infections a year, a clinician can prescribe a weekly pill for up to six months, which roughly halves how often they return. This needs a clinician's review first.
Supply and follow-up: The single dose ships as one pill. Message your care team if symptoms have not cleared in a few days, which can mean a different cause or a less common yeast that the standard pill does not cover.

The single dose is the FDA-approved treatment for an uncomplicated yeast infection. Using fluconazole on a repeating schedule for recurrent infections is an established off-label use, recommended in the CDC and ACOG treatment guidelines, and a clinician decides whether it fits.

Every order includes

A prescription
Shipped to your door
Clinician messaging

What the evidence says

One dose clears most infections. A single 150 mg dose of fluconazole cures about 90% of uncomplicated yeast infections, the long-standing benchmark in the literature (Sobel, New England Journal of Medicine 2004; CDC STI Treatment Guidelines 2021).
It works about as well as the creams. Across randomized trials, single-dose oral fluconazole and the topical azole creams (clotrimazole, miconazole) clear uncomplicated infections at similar rates. Most people simply prefer one pill to a week of nightly inserts (Cochrane review of oral versus intravaginal antifungals).
A weekly pill cuts recurrences for those who get them often. In women with recurrent infections, six months of weekly fluconazole roughly halved how often they came back compared with placebo, with the benefit fading after the medicine stopped (Sobel, New England Journal of Medicine 2004). This is the basis for the maintenance plan above.
It is first-line in the guidelines. Both the CDC 2021 STI Treatment Guidelines and ACOG list single-dose oral fluconazole as a first-line treatment for uncomplicated vulvovaginal candidiasis.

Read the full clinical reference for fluconazole →

Known risks and side effects

A single 150 mg dose is well tolerated by most people. The questions in the intake screen for the situations below, and a few are reasons we will not prescribe it online.

Reasons we will not prescribe it here

Pregnancy. Oral fluconazole is avoided in pregnancy, where repeated or higher doses have been linked to birth defects. A topical cream treats a yeast infection safely while you are pregnant, so the intake stops the pill and points you there.
Warfarin. Fluconazole raises the effect of the blood thinner warfarin and can cause serious bleeding. The intake stops this combination and routes you to the clinician who manages your warfarin.
An allergy to azole antifungals. If you have reacted to fluconazole, clotrimazole, miconazole or a related antifungal, the intake stops here so a clinician can review what happened.
Liver disease. Fluconazole is cleared by the liver, so a history of liver problems needs a clinician who can check your liver health in person.

Drug interactions to tell us about

Statins. Fluconazole can raise the level of some cholesterol statins (simvastatin, lovastatin) and the small risk of muscle injury that comes with them. A single dose is low risk, and a clinician reviews the combination.
Heart-rhythm medicines. Fluconazole can lengthen the heart's QT interval and affects how some heart-rhythm medicines are cleared. A clinician checks the specific medicine before prescribing.

Common and serious side effects

Common. Headache, nausea and mild stomach upset. They are usually brief after a single dose.
Serious and rare. Liver injury and a serious skin reaction (rash with blistering) are rare and far more associated with long courses than a single dose. Stop the medicine and seek care for a spreading rash, yellowing of the skin or eyes, or severe stomach pain.

How it works here

You answer an intake. Questions about your symptoms, whether you could be pregnant, the medicines you take and how often you get these infections. About five minutes. Disqualifying answers stop the flow before you pay.
A licensed clinician reviews it. Most reviews finish the same day. A first-ever infection, frequent infections or symptoms that do not fit a yeast infection are reviewed more closely, and the clinician may suggest a quick exam or swab to confirm.
The pharmacy ships your pill. If it fits, fluconazole ships to your door. The single dose is one pill; a recurrent or maintenance plan ships as the clinician prescribes it.

No appointment, no video call. A licensed clinician reviews your intake and prescribes if appropriate, entirely online.

Price

Two flat charges: the visit and the medication. No membership.

Pricing
Clinical visit and prescription	$25
Single-dose treatment (150 mg)	$15
Recurrent course (three doses, days 1, 4 and 7)	$25
Maintenance, weekly for 6 months	$54

No insurance needed
Ships to your door
No membership fee

These are evidence-based prescription medications, dispensed by licensed pharmacies. An intake that ends at a safety rule before review is never charged.

FAQ

Is this the same as Diflucan?

Yes. Diflucan is the original brand name for fluconazole. We prescribe the generic, which is the same medicine at a lower price.

How fast does it work?

Itching often eases within a day. The rest of the symptoms settle over two to three days. If you are not clearly better in a few days, message us, because that can mean a different cause or a less common yeast that the standard pill does not cover.

Why does fluconazole need a prescription in the US when it doesn't elsewhere?

In the UK, Canada and Australia a pharmacist can supply it after a short conversation. In the US it has stayed prescription-only, mostly for historical reasons rather than because the medicine is riskier here. We give you a quick way to get that prescription.

Can I just use a cream instead?

Yes. Over-the-counter clotrimazole and miconazole creams work about as well for an uncomplicated infection. Many people choose the pill because it is one dose rather than several nights of inserts. Both are reasonable.

I get these all the time. Can you help?

Yes. Four or more infections in a year is worth a closer look. A clinician will review what is driving them and can prescribe a weekly pill for up to six months, which roughly halves how often they return.

Can I take it if I'm pregnant?

Not the oral pill. Fluconazole by mouth is avoided in pregnancy. A topical antifungal cream treats a yeast infection safely while you are pregnant, and a pharmacist or your OB can point you to one.

From the catalog · Fluconazole

Start your intake

Answer the intake and a licensed clinician reviews it, usually the same day. If fluconazole fits, it ships to your door.

See if I qualify

Clinical content reviewed by [Reviewer name], MD. Last clinically reviewed 2026-06-17.